The p65 subunit of NF-κB or HIF-1α is downregulated by siRNA to reverse the EMT phenotype under hypoxic conditions in vitro, inhibits the proliferation of pancreatic cancer cell lines (PANC-1, BxPC3), induces apoptosis, and enhances the efficacy of gemcitabine in treating pancreatic cancer [107]. This evidence concerns the gene HIF1A and familial pancreatic carcinoma.