When evaluating the percentage of CD4 and CD8 T cells out of total tumor cell numbers, there was a significant increase of both CD4- and CD8-positive cells in tumors of mice treated with the combination of Poly(I:C)+ OX40+ TIM-3 when compared to those treated with PBS (Figure 7N,O, p < 0.05). This evidence concerns the gene TNFRSF4 and neoplasm.