SMAD4 and neoplasm: Numerous mosaic CNVs were also revealed, including deletions of the whole chromosome 9, long arm of chrs 8 and 18, short arm of chr 17 and segments of chrs 4q and 12p, overall affecting several tumor suppressor genes, such as TPP53 (17p13.1), SMAD2 (18q21.1), SMAD4 (18q21.2), DCC (18q21) and the WNT antagonist SFRP2 (4q31.3) (Figure 4 and Table S5).