Meanwhile, a more direct correlation was studied by Calcinotto et al. [61], which showed that the level of IL-17 in the bone marrow of VK*MYC mice increased at the MGUS stage, and was then closely related to the progression of smoldering MM to MM, suggesting that the higher levels of IL-17 in bone marrow increase the susceptibility of smoldering MM to MM. The gene discussed is MYC; the disease is Miyoshi myopathy.