Likewise, lysine-specific histone demethylase 1A (LSD1) ablation by CRISPR/Cas9-mediated disruption led to double-stranded RNA (dsRNA) stress and activation of type-1 interferon, thus stimulating tumor immunogenicity, anti-tumor T-cell immunity, and CD8+ T-cell infiltration. The gene discussed is CD8A; the disease is neoplasm.