PDCD1 and neoplasm: In a recent work by Zou F. et al. triple ablation of inhibitory receptors PD-1, TIM-3, and LAG-3 by short hairpin RNA (shRNA) in anti-Her2 CAR-Ts resulted in their epigenetic reprogramming and increased chromatin accessibility of the CD56 gene as well as key genes, including IFN-γ, TNF-α, and Bcl-2; their enhanced transcriptional expression in combination with transcriptional upregulation of chemokines including CXCL9, CXCL10, CXCL12 led to enhanced CAR-T infiltration into the tumor and thus superior disease control in murine models [101].