Protein arginine methyltransferase 5 (PRMT5) has a great impact on T-cell differentiation and function [175] through the induction of cholesterol biosynthesis, while specific Prmt5 deletion in CD4+ T cells suppressed Th17 cell differentiation and protected mice from developing experimental autoimmune encephalomyelitis [176]. Here, PRMT5 is linked to experimental autoimmune encephalomyelitis.