By assessing the epigenetic profile of T cells obtained from mice implanted with pancreatic ductal adenocarcinoma (PDA) cells and either treated with a cytotoxic agent that selectively ablated TAMs or left untreated, it was found that in the absence of TAMs, the TME was highly populated with epigenetically remodeled IL-10, T-bet, and PDCD1 promoters, CD4+ and CD8+ T-cell fractions, forming an anti-tumor phenotype [161]. This evidence concerns the gene CD8A and neoplasm.