For instance, in non-small-cell lung cancer (NSCLC), the (down)regulated expression of the miR-29 family (29a, 29b, and 29c) that normally exhibits a tumor suppressive potential and is associated with a poor prognosis is inversely correlated with the (over)expression of the DNA methyltransferases DNMT3A and DNMT3B, which can be directly targeted by miR-29s. Here, DNMT3A is linked to neoplasm.