CXCL10 and ovarian carcinoma: Indeed, in a primary ovarian cancer model, enhancer of zeste homologue 2 (EZH2)-mediated histone H3 lysine 27 trimethylation (H3K27me3), as well as DNMT1-DNA methylation at the promoter of CXCL9 and CXCL10, suppressed the secretion of central T helper 1 (Th1) chemokines CXCL9 and CXCL10 by malignant cells, leading to inhibition of the trafficking of Teff cells into TME [103].