CXCL8 and cancer: Other SASP factors that facilitate EMT in cancer cells include the pro-inflammatory factors IL-6 and IL-8 [112,113], Serine protease inhibitor Kazal-type 1 (SPINK1) [106], amphiregulin (AREG) [107,114], epiregulin (ERPG) [115], and WNT16B [114].