A study confirmed that the expression of the chemokine growth-regulated oncogene 1 (GRO-1, also known as TRIT1) was significantly elevated in ovarian cancer, and the overexpression was shown to be triggered by RAS signaling, resulting in inducing stromal fibroblast senescence, implicating the possibility of tumor-cell-induced stromal cell senescence [64]. Here, TRIT1 is linked to ovarian carcinoma.