Cultivating three different types of breast cancer cell lines by CM derived from young and senescent HPMCs, it was observed that the secretory levels of pro-angiogenic agents, including CXCL1, CXCL8, the hepatocyte growth factor (HGF), and the VEGF, were significantly increased in cancer cells [134]. The gene discussed is CXCL8; the disease is breast carcinoma.