Multivariate analysis revealed that albumin (HR: 1.451, p < 0.001), creatinine (HR: 1.270, p = 0.003), AFP > 200 ng/mL (HR: 1.709, p < 0.001), vascular invasion (HR: 1.673, p < 0.001) and tumor size > 5 cm (HR: 1.855, p < 0.001) were independent predictors associated with shortened survival. This evidence concerns the gene AFP and neoplasm.