MTOR and isolated focal cortical dysplasia type II: One such protein associated with microtubules is tau, which is known to be overactivated (in a hyperphosphorylated state) not only in neurodegenerative conditions [21], but also in infant tauopathies—tuberous sclerosis, hemimegaloencephaly, FCD type II, etc. All these early childhood conditions involve disruptions in the mTOR signalling pathway [22].