The role of interleukin-10 was also speculated, on one hand because its elevation was associated with both migraine and H. pylori infection (cagA-positive strains, in particular), and on the other hand, due to the fact that sumatriptan (5-HT1D receptor agonist) decreases the levels of this cytokine during a migraine attack [50,51]. Here, IL10 is linked to migraine disorder.