IPMN, as the main research focus of nCLE in published studies, exhibited consistently high specificity (94.31%, 96.35%, and 87.39%) and good accuracy (83.43%, 80.68%, and 76.62%), but relatively low sensitivity (45.95%, 28.14%, and 40.48%) in CNN1-3, respectively. Here, CNN1 is linked to pancreatic intraductal papillary-mucinous neoplasm.