The limitations of the current study include a lack of determination of some related clinical history, such as sun exposure periods; a lack of detection of HPV DNA using the related primers or in situ hybridization (ISH) due to financial issues; the absence of genodermatosis in the included boy in this study; and, lastly, an inability to assess the normal skin p16 status of the included cases because the nature of this study depended on studying only the available tissue blocks in the pathology and dermatology departments. Here, CDKN2A is linked to hereditary skin disorder.