A total of 19 of 447 (4.3%) patients had anti-U11/U12 (RNPC-3) antibodies and ILD was more frequent (11, 57.9% vs. 144, 33.6%, p = 0.030) in individuals with anti-RNPC-3 antibodies. This evidence concerns the gene RNPC3 and interstitial lung disease.