In addition to these well-known autoantibodies, several other antibodies have been specifically associated with SSc, including anti-U3 ribonucleoprotein (RNP) or, more specifically, anti-fibrillarin [4,5,6], anti-Th/To [7,8,9,10,11], anti-eukaryotic initiation factor 2B (eIF2B) [12], anti-RuvBL1/2 [12,13], and anti-TERF-1 antibodies [14,15]. The gene discussed is RNPC3; the disease is systemic sclerosis.