In the univariate analysis, we observed a significant difference between patients with or without HCC regarding the following parameters: age (p < 0.001), ALT (p < 0.001), AFP (p < 0.001), AFP-L3 (p < 0.001), DCP (p < 0.001), GPC3 (p < 0.001), CK-19 (p < 0.001), serum bilirubin levels (p = 0.001), and serum albumin levels (p = 0.001). The gene discussed is GPC3; the disease is hepatocellular carcinoma.