Severe anaemia and severe iron overload were found in HbE/β-thalassaemia patients with the novel compound mutation Cd 26 (GAG>AAG) Hb E (βE) and (β0)-thalassaemia Filipino-45 kb deletion, as well as the new triplicate mutations Cd 41/42 (-TTCT) (β0), IVS 1-5 (G>C) (β+), Cd 26 (G>A), Hb E (βE), IVS 1-2 (T>C) (β+), and Cd 26 (GAG>AAG) Hb E (βE). The gene discussed is GSTM1; the disease is Tangier disease.