HAMP and Increased total leukocyte count: Patients with Cd 41/42 (-TTCT) (β0), IVS 1-5 (G>C) (β+), and Cd 26 (G>A) HbE (βE) also have severe anaemia with significant thrombocytosis and leukocytosis, as well as significantly increased serum ferritin levels and decreased serum hepcidin levels, compared to patients with other mutations.