In the present study, the haematological parameters and iron profiles in patients with novel mutations of β-thalassaemia, such as Cd 26 (GAG>AAG) HbE (βE) and (β0)-thalassaemia Filipino-45 kb deletion, IVS 1-2 (T>C) (β+) and Cd 26 (GAG>AAG) HbE (βE), Cd 41/42 (-TTCT) (β0), IVS 1-5 (G>C) (β+) and Cd 26 (G>A) HbE (βE), and Cd 41/42 (-TTCT) (β0), IVS 1-5 (G>C) (β+), and Cd 17 (A>T) (β0), were compared with those in patients with compound heterozygous β-thalassaemia. Here, HBE1 is linked to thalassemia.