In our study, the analysis of the relationship between the main causes of death and the frequency of KIR genes in patients with ascites and encephalopathy did not show statistically significant differences that could demonstrate an increase or decrease in susceptibility to a specific death cause, except for KIR3DL1. Patients without encephalopathy in AC showed increased GF frequency compared to patients with encephalopathy, corroborated by multivariate logistic regression analysis. This evidence concerns the gene KIR3DL1 and Encephalopathy.