APC and Familial adenomatous polyposis: Supernumerary teeth are associated with malformation syndromes, including APC-associated familial adenomatous polyposis, RUNX2-associated cleidocranial dysplasia [11], TRPS1-associated tricho-rhino-phalangeal syndrome [10,12,13,14], ROR2-associated Robinow syndrome, and CREBBP-associated Rubinstein–Taybi syndrome [11].