In conclusion, the magnitude of this study allowed assessment of relationships between clinico-pathological factors and Ki67baseline, POAI-induced and untreated ∆Ki672week and Ki672week with high degrees of confidence, in particular, illustrating that POAI-induced ∆Ki672week was independent of tumour size, nodal involvement, histology and vascular invasion but associated with both grade and PgR status. This evidence concerns the gene PGR and neoplasm.