As a result, dozens of GBM-related TAAs have been found till now, including ACTL8, CTCFL, Opa interacting protein 5 (OIP5), XAGE3, CD133, epidermal growth factor receptor vIII (EGFR vIII), Interleukin-4 (IL-4), gp100, survivin, Interleukin-13 receptor subunit alpha-2 (IL-13Rα2), Human Epidermal Growth Factor Receptor 2 (HER2), Human Chitinase-3-like Protein 1 (YKL-40), and erythropoietin-producing hepatocellular receptor tyrosine kinase class A2 (EphA2) [29] with evaluation in early-stage therapeutic preclinical trials demonstrating the safety and immunogenicity in human body. The gene discussed is CHI3L1; the disease is glioblastoma.