CD8A and neoplasm: Another comparative study on tumor immunologic features found that in comparison with the tissue sample from newly diagnosed GBM, tumor tissue of rGBM showed much higher levels of infiltration of CD4 + T cells, CD8 + T cells, CD68 + macrophages, and CD163 + macrophages [78], however no significant difference was found in the CD8 to CD4 ratio of those two groups [79].