In addition, CAFs establish immune crosstalk by secreting chemokines and cytokines such as IL-6, TGF-β, and CXCL12, thereby interfering with T cell function and recruiting myeloid-derived suppressor cells (MDSC), regulatory T cells (Treg) and tumor-associated macrophage (TAM) [11, 12]. Here, CXCL12 is linked to neoplasm.