High serum NT-proBNP levels heavily impact MIS-C prognosis, as they are associated with a greater disease burden, reflected by the presence of hypotension and/or circulatory shock, hyperinflammation, hypoalbuminemia, ventricular dysfunction on echocardiogram, chest X-ray abnormalities, and the need for pediatric intensive care. This evidence concerns the gene NPPB and Hypoalbuminemia.