In our cohort, identified risk factors for pediatric intensive care were clinical signs of circulatory shock and/or hypotension, laboratory evidence of SARS-CoV-2 exposure, hyperinflammation, high D-dimer levels, hypoalbuminemia, evidence of myocarditis, including high NT-proBNP or troponin levels and ventricular dysfunction on echocardiogram, and the presence of chest X-ray abnormalities. Here, NPPB is linked to myocarditis.