As part of regular surveillance for breast cancer, PV/LPV carriers of BRCA1/2 are recommended for annual breast magnetic resonance imaging and breast mammogram as early as age 25 years and hence, it may be prudent for physicians to advise COVID-19 vaccine recipients to defer imaging scans minimally a few weeks post-vaccination to avoid false positives for pathological conditions. The gene discussed is BRCA1; the disease is breast carcinoma.