Previous studies have shown significant advances in factors likely involved in PCOS pathogenesis, including the potential roles of androgen, insulin, AMH, TGFβ, oxidative stress, pro-inflammatory cytokines, advanced glycation end products (AGEs), and so on [3, 4], among which the HA seemed to be the most vital determinant of the PCOS pathophysiology and the associated metabolic dysfunction [5]. The gene discussed is TGFB1; the disease is polycystic ovary syndrome.