CRH and Anxiety: It is known that psychosocial stress, loneliness, anxiety, and aging itself can jointly distress the neuroendocrine system, by stimulating the hypothalamic-pituitary-adrenal (HPA) axis to produce the corticotropin-releasing hormone (CRH) from the hypothalamus and thus trigger the anterior pituitary gland to release adrenocorticotropin (ACTH) (Fig. 2, B).