Gene-level analysis showed that 11 genes were subject to differential CN-independent ASE between normal and tumour tissue when controlling for repeated measures: NTM (more frequent CN-independent ASE in normal tissue); and NLRP2, PRIM2, CSNK2A3, GALNT18, ZNF597, RAB5B, RRM1, CAST, PDE4DIP and LOC653513 (more frequent CN-independent ASE in tumours) (Extended Data Fig. 2e). The gene discussed is ZNF597; the disease is neoplasm.