SEMA3A and obesity due to melanocortin 4 receptor deficiency: By cross-referencing the differential gene expression profiles generated from bulk tumour analysis with a list of 400 genes derived from published reports relating to obesity and cachexia, we identified Semaphorin-3A (SEMA3A), Insulin-like growth factor 1 (IGF1), the potassium channel KCNJ12, and A-kinase anchor protein 6 (AKAP6) to have increased differential expression in the CAC group 56.