Driver mutations in the Wnt pathway were enriched in STAS positive tumours, (q = 0.033, Fisher’s exact test, FDR adjusted) (Extended Data Fig. 8a), and the bulk tumour transcriptomic profiles showed higher CTNNB1 gene expression (P = 0.0076, linear mixed effect model, ANOVA) (Extended Data Fig. 8b). Here, CTNNB1 is linked to neoplasm.