MKI67 and neoplasm: When the proportion of each individual growth pattern was compared against these genomic features, the presence of highly proliferative and recent subclonal expansion was most strongly associated with the proportion of the solid-pattern component within a tumour (Ki-67 fraction, rho = 0.51, q = 8.1 × 10-11, recent subclonal expansion score, rho = 0.19, q = 0.026) (Fig. 1c).