CD274 and cancer: Although there was no association observed between stromal TIL infiltration and the predominant growth pattern (Extended Data Fig. 2g), cancer cell PD-L1 expression, assessed by immunohistochemistry, was significantly higher in solid predominant tumours than all other histological subtypes (q = 4.8 × 10-7, Wilcoxon rank sum test, Extended Data Fig. 2h), as previously reported14.