KLK3 and posterior cortical atrophy: The 389 patients included in the final analysis presented a median age of 67.2 years (interquartile range [IQR] 43–85), median total PSA value of 8.42 ng/mL (IQR 0.08–86.20), and median PSA density of 0.19 ng/mL/mL (IQR 0.002–1.60), with a statistically significant difference in PSA density between patients without PCa or having ciPCa and csPCa (0.13 vs 0.16 vs 0.3, p < 0.001).