We found that lncRNA-MEG3 had the best overall prediction of response to steroids and the need for splenectomy in ITP patients compared to miR-125a-5p, CXCL13, and NF-kB, which make lncRNA-MEG3 a potential prognostic marker in the management of ITP. The gene discussed is NFKB1; the disease is autoimmune thrombocytopenic purpura.