Although the upstream mechanism by which the Staphylococcus infection down regulates PR is not known, the down-stream pathways mediated by PR is likely involve MYC149, Bcl-2150, STAT1151, MAPK152, and/or mTOR153.mTOR complexes are well established to regulate, among other things, protein synthesis and cell survival pathways154,155. Here, PGR is linked to staphylococcus aureus infection.