HMBS and cholangiocarcinoma: Furthermore, we found that the down-regulated DEmRNAs except SRM all came from the mTORC1 signaling pathway and targeted by has-miR-143-3p, including SLC7A5, SLC7A11, TUBG1, GPI, HMBS, PNP, PDAP1, CDC25A and PSMC4. Notably, Yothaisong et al. had verified that BEZ235 caused a reduction in SLC7A5 expression in parallel with a reduction of activated AKT and mTOR in cholangiocarcinoma cell37.