Previous research found that Yifei Sanjie Recipe alleviated pulmonary fibrosis by reducing the phosphorylation level of phosphatidylinositol3-kinase (PI3K) and protein kinase B (AKT), upregulating the expression of autophagy marker protein, enhancing autophagy, reducing the content of HYP and the expression of COL-I and COL-III in pulmonary tissue38. Here, AKT1 is linked to pulmonary fibrosis.