ACE2 and COVID-19: Since high testosterone serum levels increase expressions of the angiotensin-converting enzyme-2/serine transmembrane protease serine 2 (ACE2/TRMPSS2) axes, which is essential for the entry and pathogenesis of SARS-CoV-2, it has been demonstrated that a reduction in testosterone levels in COVID-19 and LC patients may be a counter-balancing protective mechanism against SARS-CoV-2 propagation and induced complications45.