Consistent with the most pronounced expansion of (stem-like) tumor-specific CD8+ T cells in blood (Fig. 2d, g and Fig. 3h), we found the strongest expansion (>10-fold) of CD28+ tumor-specific CD8+ T cells also in blood of triple-treated vs. RT/anti-PD1-treated mice (Supplementary Fig. 7a–c). Here, CD28 is linked to neoplasm.