Consistent with that, we found in triple-treated mice fewer Tox-expressing (Fig. 4b, Supplementary Fig. 8a) and more T-bet-expressing tumor-specific CD8+ T cells (Supplementary Fig. 8b, c), and more TILs secreting the effector cytokines IFNγ and TNF including more polyfunctional IFNγ+TNF+ TILs, as well as cells positive for CD107a, a degranulation marker of cytotoxic T cells (Fig. 4c, d, and Supplementary Fig. 8d). Here, CD8A is linked to neoplasm.