As presented in Fig. 7a (for the B16-CD133 tumor model) and Supplementary Fig. 13a (for the C51 tumor model), a direct comparison of tumor-specific CD8+ T cells from peripheral blood and irradiated tumor of triple-treated mice showed that blood contained more tumor-specific CD8+ T cells with markers of undifferentiated cells (such as TCF1) and fewer with markers of differentiated cells (TIM3) than tumor tissue. The gene discussed is HAVCR2; the disease is neoplasm.