CD8A and neoplasm: In addition, tumor-specific CD8+ T cells accumulated in TDLNs (Fig. 3d), consistent with the view that RT induces tumor-specific CD8+ T cells in lymph nodes draining irradiated tumors33,34; in blood, tumor-specific CD8+ T cells decreased but, under FTY720 blockade, they still expanded 29-fold in triple-treated vs. RT/anti-PD1-treated mice (Fig. 3d).