Analysis of tetramer+ TILs from triple-treated mice in both tumor models showed that the percentage of polyfunctional (IFNγ+TNF+) cells decreased from the TCF1+TIM3-PD1+ to the CD101-TCF1-TIM3+PD1+ to the CD101+TCF1-TIM3+PD1+ subset (Fig. 4e, f; Supplementary Fig. 8e, f). The gene discussed is HAVCR2; the disease is neoplasm.