By concomitantly adding either CD8β-depleting or CXCR3-blocking antibodies to triple treatment, we found that both CD8+ and CXCR3+ cells were crucial for the abscopal effect as adding these antibodies completely attenuated abscopal tumor control and significantly worsened mouse survival (Fig. 6d, e, h, i). This evidence concerns the gene CD8A and neoplasm.