CD8A and neoplasm: Consistent with the large increase in undifferentiated tumor-specific CD8+ T cells with high proliferative capacity in the blood circulation, we observed a CD8- and CXCR3-dependent enhancement of the RT-induced abscopal effect against a distant, non-irradiated tumor and found that blood-derived CD8+ T cells generated by such a triple treatment can be a rich source of tumor antigen-specific CD8+ T cells for ACT.