MTOR and acute lymphoblastic leukemia: When treating with the mTOR inhibitor everolimus in the T-ALL PDX model, they observed an increased level of ROS accompanied by a decreased capacity of ROS scavenging and significant therapeutic effects.184 Zhang et al. treated a KRAS G13D mutant CRC PDX model with cetuximab and detected the expression level changes of different genes, thereby determining potential genes contributing to acquired resistance.185 Another study investigated the mechanism of EGFR inhibitor resistance and discovered that the remaining tumor cells after EGFR treatment have high HER-2 and HER-3 activity.