IL-15 could promote NK cell maturation and function, with which the anti-disialoganglioside (GD2) antibody (mediating antibody-dependent cell-mediated cytotoxicity (ADCC)) exhibited an improved tumor-killing effect in neuroblastoma PDX.205 The immune response can be further activated by targeting CD105, specifically expressed on immunosuppressive cells such as mesenchymal stromal cells, tumor-associated macrophages, and cancer-associated fibroblasts. This evidence concerns the gene IL15 and neoplasm.