We genetically depleted endogenous DAXX, overexpressed wild-type (WT) DAXX, or a mutant in which both SIM1 and SIM2 (I7K/I733K or DSM) required for binding to SUMO are disabled28 in the triple-negative BC (TNBC) cell line MDA-MB-231 (Fig. 1a). The gene discussed is SIM1; the disease is breast cancer.