BRCA1 and serous adenocarcinoma: The average age of diagnosis of high-grade serous carcinoma is 51–53 years for BRCA1 and 55–60 years for BRCA2 pathogenic variant carriers15 and evolutionary analysis demonstrated a 7-year interval between serous tubal intraepithelial carcinoma and invasive high-grade serous carcinoma.7 8 Therefore, we hypothesize that salpingectomy is most effective when performed at a maximum age of 40 years for BRCA1 and 45 years for BRCA2 pathogenic variant carriers.