Since TNF-α induces migration of LC to LN, we investigated whether melanoma-activated LC had the potential to stimulate naïve T cells upon migration to tumor-draining LN in our murine model and analyzed expression of the costimulatory molecule CD86 on LC compared to other resident (B cells, CD11c+MHCII+ DC) and migrating (CD11c+MHCIIhigh DC) antigen-presenting cells. The gene discussed is ITGAX; the disease is neoplasm.