To determine whether LCs respond to melanoma growth in the epidermis, we established a clinically relevant syngeneicinjectable murine melanoma model using the YUMM1.7(BrafV600E/WTCdkn2a−/− Pten−/−) cell line (31) and measured the frequency of epidermal LCs [CD11b+MHCII+CD24+EpCam+ cells; fig. Here, EPCAM is linked to melanoma.