FMR1 and ovarian dysfunction: Locus POF1 involvesthe segment between Xq26 to Xqter, while locus POF2 involves the segment betweenXq13.3 to Xq22.10,11,16 Locus POF1 and locus POF2 are clinically associated with ovarian failure inpatients aged 24–29 years old and in those aged 16–21 years old, respectively.18 In our sample, the two patients presenting deletions involving POF1 (regionsq22q28 and q24q28) were diagnosed with ovarian failure at 27 and 28 years old,respectively.