TP53 and cancer: MEGS analysis in GSEA revealed that differential genes were mainly enriched in cell cycle, signal transduction, and cancer pathways, including reactome cell cycle, Kegg focal adhesion, reactome extracellular matrix organization, reactome post-translational protein modification, and reactome transcriptional regulation by tp53 and the wp pi3kakt signaling pathway (Figure 5(B,E) and Table 3).