PIK3CA and endocervical adenocarcinoma: Figure 1(A) shows the heat map of the top 20 up- and down-regulated MEDS, and Figure 1(C) shows the volcano map of the top 20 up- and down-regulated MEDS. The genes with higher mutation frequency in MEGs, in descending order, were TTN, PIK3CA, MUC4, MUC16, DMD, and FLG (Figure 1(D)). The variations included amplifications, deletions, mutations, and complex alterations. The largest proportion of mutation frequency was found in the up-regulated gene set of endocervical adenocarcinoma (Figure 1(B)).