PIM1 levels are elevated in high-grade prostatic intraepithelial neoplasia relative to normal tissue and further elevated in castration-resistant prostate cancer (Dhanasekaran et al., 2001), and high PIM1 expression is associated with resistance to therapy (Logothetis et al., 2018). This evidence concerns the gene PIM1 and prostate intraepithelial neoplasia.