In favor of attributing the seemingly contrasting observations in blood CD1c+ subsets between SLE and non-infectious uveitis to distinct biology is the fact that, in contrast to elevated IFN-α in patients with SLE, in non-infectious uveitis patient’s disease exacerbations correlate with reduced blood type I IFN concentrations (Wang et al., 2019; Kuiper et al., 2022; Obermoser and Pascual, 2010). This evidence concerns the gene CD1C and uveitis.