The differences between non-infectious uveitis and SLE may be related to distinct (i.e., opposite) immunopathological mechanisms; Type I IFNs drive the maturation of cDC2s into ‘inflammatory cDC2s’ (infcDC2s) (Bosteels et al., 2020) and can induce CD1c+ DCs to express a distinct set of surface receptors (Girard et al., 2020). Here, CD1C is linked to systemic lupus erythematosus.