MMP13 and hereditary clear cell renal cell carcinoma: On the other hand, lncRNA SARCC was found to bind and destabilize AR protein in renal cell carcinoma, leading to reversing the effect of transcriptional repression by miR‐143‐3p, inhibiting its downstream signals such as AKT, MMP‐13 (matrix metalloproteinase 13), K‐RAS (Kirsten rat sarcoma virus) and P‐ERK (PKR‐like endoplasmic reticulum kinase; Zhai et al., 2017).