The lncRNA HOTAIR interacts with AR (androgen receptor) and they cooperatively bind to GLI2 promoter, increasing its transcription activity in renal cell carcinoma cells, enhancing the expression of GLI2 downstream genes, such as VEGFA, PDGFA, and cancer stem cell transcription factors, promoting tumor angiogenesis and cancer stemness both in vitro and in tumor xenografts (Bai et al., 2021). The gene discussed is GLI2; the disease is cancer.