CircRNA PRMT5 (protein arginine methyltransferase 5) is upregulated in breast cancer tissues and cells and increases TCF7L2 (transcription factor 7 like 2) expression by acting as a miR‐509‐3p sponge (D. Wu et al., 2021), in turn activating the phosphoinositide 3‐kinase (PI3K)/AKT pathway. The gene discussed is AKT1; the disease is breast carcinoma.