On the other hand, lncRNA SARCC was found to bind and destabilize AR protein in renal cell carcinoma, leading to reversing the effect of transcriptional repression by miR‐143‐3p, inhibiting its downstream signals such as AKT, MMP‐13 (matrix metalloproteinase 13), K‐RAS (Kirsten rat sarcoma virus) and P‐ERK (PKR‐like endoplasmic reticulum kinase; Zhai et al., 2017). This evidence concerns the gene AR and hereditary clear cell renal cell carcinoma.