In bladder cancer, lncRNA FOXD2‐AS1 (FOXD2 adjacent opposite strand RNA 1) forms an RNA–DNA complex with the promoter of TRIB3 (Tribbles Pseudokinase 3), that leads to the activation of AKT (Serine–Threonine Protein Kinase), which further increases the expression of E2F1 (E2F transcription factor 1), a vital transcription factor involved in the G/S transition (F. Su et al., 2018). The gene discussed is E2F1; the disease is urinary bladder cancer.