It was shown recently that the ATP‐dependent chromatin remodeling INO80 (INO80 Complex ATPase Subunit) complex promotes resolution of R‐loops to prevent replication‐associated DNA damage in cancer cells, while depletion of INO80 in prostate cancer cells leads to increased R‐loops (Prendergast et al., 2020). Here, INO80 is linked to prostate carcinoma.