Additionally, SNHG1 interacts with EZH2 component of Polycomb Repressive Complex 2 (PRC2) and can thus modulate the histone methylation of promoter of Kruppel‐like factor 2 (KLF2) and Cyclin dependent kinase inhibitor 2B (CDKN2B) in the nucleus promoting colorectal cancer cell growth by affecting cell cycle progression and apoptosis. The gene discussed is CDKN2B; the disease is colorectal cancer.