On the contrary, M2 macrophages can induce tumor immunosuppression and promote tumor progression through releasing proinflammatory cytokines including IL-10/12/13/16, INF- γ and transforming growth factor- β (Chen et al., 2019; Jeannin et al., 2018; Sica et al., 2006; Yunna et al., 2020), and tumor-associated neutrophil was another important member of TIICs and can release several factors leading to tumor progression (Eruslanov, 2017; Galdiero et al., 2013; Mantovani et al., 2011). The gene discussed is IL10; the disease is neoplasm.