CD40LG and cancer: Active EBV infection and replication should be considered if EBV IgM antibody and DNA are positive, and the possibility of chronic active EBV infection or EBV-associated hemophagocytic lymphohistiocytic hyperplasia (Kien & Ganta, 2020) and other malignant neoplasms should be kept in mind if EBV-DNA copy number continues to increase.