TMEM27, a homologueof ACE2,31 has previously been reportedas being co-regulatedwith ACE2 in bronchial samples.54 Giventhe prominent role of ACE2 in increased susceptibility in cancer patientsand TMEM27 exhibiting 47% homology to ACE2 functions, we speculatethat TMEM27 might be involved in the increased susceptibility in cancerpatients for COVID-19. This evidence concerns the gene CLTRN and cancer.