Furthermore, by analyzing the sequencing data obtained from clinical samples from the GEO database, we identified a variety of related drugs that did not cause significant downregulation of TFRC expression in AML cells, as well as 2 individual drugs and 1 combination drug that caused significant downregulation of TFRC expression in AML cells, which provided important reference data for our further efforts to develop a targeted drug delivery system based on HFn. Here, TFRC is linked to acute myeloid leukemia.