Although the available effective data are only a little, it is exciting that our analysis results suggested that the expression level of TFRC in AML cells from AML patients was upregulated after Ara-C treatment in vitro (GSE145061, Additional file 1: Fig. S1c) and that the expression of TFRC was transiently downregulated in transgenic mice transplanted with AML patient cells (GSE146592, Additional file 1: Fig. S1d). This evidence concerns the gene TFRC and acute myeloid leukemia.