Second, although NT-proBNP is inversely associated with the incidence of DM [22–24], a study including 1294 individuals showed that NT-proBNP was positively associated with microvascular (HR: 1.20; 95% CI: 1.01–1.43) and macrovascular (HR: 1.37; 95% CI: 1.03–1.83) complications in those with incident DM [24], which have a deleterious impact on human health. The gene discussed is NPPB; the disease is diabetes mellitus.