When NT-proBNP was considered as a continuous variable, 1-SD NT-proBNP increase was significantly associated with mortality risk in ischemic HF patients (HR: 1.46, 95% CI: 1.31–1.62) even after adjusting for the covariates, and the association was more pronounced in those with DM (HR: 1.65, 95% CI: 1.43–1.91) than those without (HR: 1.28, 95% CI: 1.09–1.50) (P-interaction = 0.016). The gene discussed is NPPB; the disease is hydrops fetalis.