In addition, MSCs can regulate the Th1/Th2 cell balance and promote Tregs, as shown by suppressing Th1-type cytokines, such as IFN-γ and TNF-α, and enhancing Th2-type cytokines, such as IL-4, ultimately restoring immune tolerance and alleviating ITP [36]. This evidence concerns the gene TNF and autoimmune thrombocytopenic purpura.