PD is characterized by the death of dopaminergic neurons containing Lewy bodies (LB) composed mainly of alpha-synuclein (α-Syn) in the substantia nigra (SN), which provide the final diagnostic and pathological features for postmortem examinations [5, 6]. The α-Syn protein is a small acidic synaptic protein made up of 140 amino acids with a tendency to misfold and aggregate [7]. The gene discussed is SNCA; the disease is Parkinson disease.