ICAM4 and ischemic stroke: In the IVW analysis fitting fixed effects model, genetically determined high ICAM-4 levels were associated with increased risks of ischemic stroke (OR per SD increase: 1.04; 95% CI: 1.01–1.07; P = 0.003) and CES (OR per SD increase: 1.08; 95% CI: 1.03–1.13; P = 0.003) but not with LAS (OR per SD increase: 1.06; 95% CI: 0.99–1.13; P = 0.090) and SVS (OR per SD increase: 1.03; 95% CI: 0.97–1.09; P = 0.338).